Vol.80, No.11 November 2018
Explanation of the cover photograph
How does Toxoplama gondii invade host cells?
Kentaro KATO (pp. 1702–1706)
Details of the moving junction (MJ) in the Toxoplasma invasion system. The glideosome-associated proteins (GAP40, GAP45, and GAP50) form a complex with GAPM in association with alveolin. MLC1 interacts with MyoA with GAP45. This motor complex is anchored to the inner membrane complex (IMC) by GAP40 and GAP50. The small arrow indicates the direction of the MyoA power stroke. The MJ complex is formed by the AMA1-RON (RON2, RON4, RON5, and RON8) complex and MIC protein-host cell surface receptors, connected by aldolase. The MJ complex links the host cytoskeletons.
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