Explanation of the cover photograph

Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs

Nozomi SHIWA ET AL. (pp. 1818–1821)

Transverse sections of the tactile hair (follicle sinus complexes, FSC) in the muzzle skin of a rabid dog. Virus antigens (arrowheads) and virus genome (arrowheads, insert) were concentrated in the cytoplasm of Merkel cells in a part of the outer root sheath of the FSC at the level of the ring sinus. Small amounts of virus antigen (arrows) are also observed in the peripheral nerves of ordinary hair follicles. HS: hair shaft, OS: outer root sheath, RS: ring sinus. Immunohistochemistry, bar=100 μm (insert, in situ hybridization, bar=25 μm).

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PubMed Central