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Effects of pentosan polysulfate and polysulfated glycosaminoglycan on chondrogenesis of canine bone marrow-derived mesenchymal stem cells in alginate and micromass culture
Eugene C. BWALYA et al. (pp. 1182-1190)

Chondrogenic phenotype evaluation by Alcian blue stain analysis for proteoglycan (PG) synthesis by canine bone marrow-derived mesenchymal stem cells (cBMSC) cultured for 12-days as micromass in 10% fetal bovine serum (FBS) supplemented Dulbecco’s Modified Eagle Medium (10% DMEM), chondrogenic differentiation medium (CDM) and in CDM supplemented with either pentosan polysulfate (PPS) sodium or polysulfated glycosaminoglycan (PSGAG).
(A) cBMSC cultured in 10% DMEM predominantly proliferated as monolayer fibroblastic-like cells with limited chondrogenic condensation. (B) Chondrogenic condensation of cBMSC was more pronounced in CDM compared to the NC although PG synthesis was not different. (C) When compared to 10% DMEM and CDM, both PPS (C-E) and PSGAG (F-H) tended to enhance chondrogenic pelleting and PG deposition.

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PubMed Central